2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2589
    Isosaponarin 19416-87-6 99.59%
    Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects.
    Isosaponarin
  • HY-N2785
    Desmethylicaritin 28610-31-3 99.77%
    Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway.
    Desmethylicaritin
  • HY-N3026
    Soyasaponin Ab 118194-13-1 ≥99.0%
    Soyasaponin Ab is an orally active soyasaponin. Soyasaponin Ab inhibits PPARγ transcriptional activity. Soyasaponin Ab induces apoptosis in high concentrations. Soyasaponin Ab exerts anti-obesity, anti-oxidation, anti-inflammation, anti-aging effects. Soyasaponin Ab prevents Scopolamine (HY-N0296)-induced memory impairment.
    Soyasaponin Ab
  • HY-N4318
    Graveobioside A 506410-53-3 99.28%
    Graveobioside A is an anthoxanthin glycoside.
    Graveobioside A
  • HY-N6660
    Trisdecanoin 621-71-6 98.0%
    Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics.
    Trisdecanoin
  • HY-N7388
    3-Hydroxy-2-methylbutanoic acid 473-86-9 98%
    3-Hydroxy-2-methylbutanoic acid is a short-chain carboxylic acid and a normal urinary metabolite produced via isoleucine catabolism, fatty acid β-oxidation and ketogenesis. 3-Hydroxy-2-methylbutanoic acid exists as an acylated residue in resin glycosides derived from plants of the Ipomoea genus. 3-Hydroxy-2-methylbutanoic acid can be used in studies related to β-ketothiolase deficiency.
    3-Hydroxy-2-methylbutanoic acid
  • HY-N7575
    Lacto-N-fucopentaose II 21973-23-9 98.0%
    Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy.
    Lacto-N-fucopentaose II
  • HY-N8016
    Nonanal 124-19-6 99.42%
    Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
    Nonanal
  • HY-P0034
    Ac-DEVD-CMK 285570-60-7 98.81%
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or Ingenol 3,20-dibenzoate?(HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis.
    Ac-DEVD-CMK
  • HY-P0149
    Katacalcin 85916-47-8 98.29%
    Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide.
    Katacalcin
  • HY-P1123
    MEDICA16 87272-20-6 98.0%
    MEDICA16 is an orally active acetyl-CoA carboxylase and ATP-citrate lyase inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity.
    MEDICA16
  • HY-P1189
    Echistatin 154303-05-6
    Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1.
    Echistatin
  • HY-P1531
    γ-1-Melanocyte Stimulating Hormone (MSH), amide 72629-65-3
    γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).
    γ-1-Melanocyte Stimulating Hormone (MSH), amide
  • HY-P2776
    Hexokinase, microorganism 9001-51-8
    Hexokinase (ScHEX1) (EC 2.7.1.1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resulting in activation of NLRP3 inflammasome.
    Hexokinase, microorganism
  • HY-P2987
    L-Amino acid oxidase 9000-89-9
    L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia.
    L-Amino acid oxidase
  • HY-100227
    E 64c 76684-89-4 99.32%
    E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.
    E 64c
  • HY-101175
    3-Bromo-7-nitroindazole 74209-34-0 99.78%
    3-Bromo-7-nitroindazole is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain. 3-Bromo-7-nitroindazole can be used for the researches of metabolic and neurological disease, such as diabetes, stroke and depression.
    3-Bromo-7-nitroindazole
  • HY-103249
    Reutericyclin 303957-69-9 98.11%
    Reutericyclin (Reutericycline) is an orally active antibacterial and anti-obesity agent that selectively inhibits Gram-positive bacteria. By selectively dissipating transmembrane potential, Reutericyclin exerts non-lytic bactericidal or bacteriostatic activity against pathogens such as Clostridium difficile and Staphylococcus aureus, and rapidly kills vegetative cells and spores of Clostridium difficile. Reutericyclin possesses favorable properties including resistance to enzymatic hydrolysis, iron-chelating function, and poor absorption by colonic epithelium. Reutericyclin not only eradicates staphylococcal biofilms and inhibits drug-resistant strains, but also counteracts Risperidone (HY-11018)-induced weight gain by inducing changes in gut microbiota composition and restoring energy utilization efficiency. Reutericyclin can be used in research related to Clostridium difficile infection, Risperidone-induced weight gain, and staphylococcal superficial skin infections.
    Reutericyclin
  • HY-104051
    Monacolin J 79952-42-4 99.22%
    Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
    Monacolin J
  • HY-108017
    Ferric maltol 33725-54-1 99.93%
    Ferric maltol is an orally active monovalent iron (Fe3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease.
    Ferric maltol
Cat. No. Product Name / Synonyms Application Reactivity